Eylea (aflibercept) Injection

For the treatment of wet AMD

What to Expect During Your Visit1-3

Planning and Examination

Planning and Examination


After the Injection

Potential Side Effects Related to the Injection

Injections into the eye, including those with EYLEA (aflibercept) Injection, have been associated with an infection of the eye (endophthalmitis) in rare cases, as well as a separation of the light-sensitive membrane in the back of the eye (the retina) from its supporting layers (retinal detachment). If you experience eye pain or increased discomfort, worsening eye redness, blurred or decreased vision, flashes of light, and/or increased sensitivity to light, contact your doctor immediately because it is important to have any symptoms diagnosed and treated as soon as possible.

If any of the side effects get worse, or if you notice any side effects not listed, please tell your doctor immediately.


EYLEA® (aflibercept) Injection is a prescription medicine approved for the treatment of patients with wet AMD. The recommended dose for EYLEA is 2 mg administered by injection in the eye every 2 months (8 weeks) following 3 initial monthly (4 weeks) injections. EYLEA may be dosed once per month, but additional benefit was not seen with this dosing plan.


EYLEA® (aflibercept) Injection is a prescription medication administered by injection into the eye. You should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known allergies to any of the ingredients in EYLEA, including aflibercept. As with all medications, EYLEA can cause side effects.

Injection into the eye can result in an infection in the eye and retinal detachment. Inflammation in the eye has been reported with the use of EYLEA.

In some patients, injections with EYLEA may trigger a temporary increase in eye pressure within 1 hour of the injection. Sustained increases in eye pressure have been reported with repeated injections, and your doctor may monitor this after each injection.

There is a potential risk of serious and sometimes fatal side effects related to blood clots, leading to heart attack or stroke in patients receiving EYLEA.

The most common side effects reported in patients receiving EYLEA are increased redness in the eye, eye pain, cataract, moving spots in the field of vision, increased pressure in the eye, and vitreous (gel-like substance) detachment.

Serious side effects related to the injection procedure are rare but can occur including infection inside the eye, retinal detachment, cataract, increased pressure in the eye, and vitreous detachment.

It is important that you contact your doctor right away if you think you might be experiencing any side effects.

EYLEA is for prescription use only. For additional safety information, please talk to your doctor and see the full Prescribing Information for EYLEA.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call1-800-FDA-1088.


  1. Age-related macular degeneration: what you should know. National Eye Institute Web site.
    http://www.nei.nih.gov/health/maculardegen/nei_wysk_AMD. Accessed June 7, 2011.
  2. Wet macular degeneration. Mayo Clinic Web site.
    http://www.mayoclinic.com/health/wet-macular-degeneration/DS01086/METHOD=print. Accessed June 7, 2011.
  3. Facts about age-related macular degeneration. National Eye Institute Web site.
    http://www.nei.nih.gov/health/maculardegen/armd_facts.asp. Accessed June 7, 2011.

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